癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ACTR2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant ACTR2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P61160 |
| Other Accession | BC014546 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a kappa |
| Clone Names | 1B10-C4 |
| Calculated MW | 44761 Da |
| Gene ID | 10097 |
|---|---|
| Other Names | Actin-related protein 2, Actin-like protein 2, ACTR2, ARP2 |
| Target/Specificity | ACTR2 (AAH14546.1, 1 a.a. ~ 394 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ACTR2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene.
REFERENCES
An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability. Goley ED, et al. Proc Natl Acad Sci U S A, 2010 May 4. PMID 20404198.Distinct roles for the actin nucleators Arp2/3 and hDia1 during NK-mediated cytotoxicity. Butler B, et al. Curr Biol, 2009 Dec 1. PMID 19913427.Local network topology in human protein interaction data predicts functional association. Li H, et al. PLoS One, 2009 Jul 29. PMID 19641626.Host cell entry by apicomplexa parasites requires actin polymerization in the host cell. Gonzalez V, et al. Cell Host Microbe, 2009 Mar 19. PMID 19286135.The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility. Weisswange I, et al. Nature, 2009 Mar 5. PMID 19262673.
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