癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ADRM1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant ADRM1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, IP, E |
|---|---|
| Primary Accession | Q16186 |
| Other Accession | BC017245 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 3C6 |
| Calculated MW | 42153 Da |
| Gene ID | 11047 |
|---|---|
| Other Names | Proteasomal ubiquitin receptor ADRM1, 110 kDa cell membrane glycoprotein, Gp110, Adhesion-regulating molecule 1, ARM-1, Proteasome regulatory particle non-ATPase 13, hRpn13, Rpn13 homolog, ADRM1, GP110 |
| Target/Specificity | ADRM1 (AAH17245.1, 18 a.a. ~ 407 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 IP~~N/A E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ADRM1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is an integral plasma membrane protein which promotes cell adhesion. The encoded protein is thought to undergo O-linked glycosylation. Expression of this gene has been shown to be induced by gamma interferon in some cancer cells. Two transcript variants encoding the same protein have been found for this gene.
REFERENCES
1.Phospho-?GNp63 ? /Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells.Huang Y, Ratovitski EA.Aging (Albany NY). 2010 Dec;2(12):959-68.2.Phosphorylated TP63 Induces Transcription of RPN13, Leading to NOS2 Protein Degradation.Huang Y, Ratovitski EA.J Biol Chem. 2010 Dec 31;285(53):41422-31. Epub 2010 Oct 19.3.Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content.Pece S, Tosoni D, Confalonieri S, Mazzarol G, Vecchi M, Ronzoni S, Bernard L, Viale G, Pelicci PG, Di Fiore PP.Cell. 2010 Jan 8;140(1):62-73.
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