癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ATOX1 Antibody (monoclonal) (M08)
Mouse monoclonal antibody raised against a partial recombinant ATOX1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O00244 |
| Other Accession | NM_004045 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4D6 |
| Calculated MW | 7402 Da |
| Gene ID | 475 |
|---|---|
| Other Names | Copper transport protein ATOX1, Metal transport protein ATX1, ATOX1, HAH1 |
| Target/Specificity | ATOX1 (NP_004036, 1 a.a. ~ 68 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ATOX1 Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome.
REFERENCES
Copper(I)-mediated protein-protein interactions result from suboptimal interaction surfaces. Banci L, et al. Biochem J, 2009 Jul 29. PMID 19453293.Differential roles of Met10, Thr11, and Lys60 in structural dynamics of human copper chaperone Atox1. Rodriguez-Granillo A, et al. Biochemistry, 2009 Feb 10. PMID 19146392.Conserved residues modulate copper release in human copper chaperone Atox1. Hussain F, et al. Proc Natl Acad Sci U S A, 2008 Aug 12. PMID 18685091.Metal binding domains 3 and 4 of the Wilson disease protein: solution structure and interaction with the copper(I) chaperone HAH1. Banci L, et al. Biochemistry, 2008 Jul 15. PMID 18558714.Analysis of the human Atox 1 homologue in Wilson patients. Simon I, et al. World J Gastroenterol, 2008 Apr 21. PMID 18416466.
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