癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ATP13A2 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant ATP13A2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NQ11 |
| Other Accession | NM_022089 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4B7 |
| Calculated MW | 128794 Da |
| Gene ID | 23400 |
|---|---|
| Other Names | Probable cation-transporting ATPase 13A2, 363-, ATP13A2, PARK9 |
| Target/Specificity | ATP13A2 (NP_071372, 68 a.a. ~ 154 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ATP13A2 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Mutational analysis of GIGYF2; ATP13A2 and GBA genes in Brazilian patients with early-onset Parkinson's disease. Dos Santos AV, et al. Neurosci Lett, 2010 Sep 14. PMID 20816920.Structural imaging in the presymptomatic stage of genetically determined parkinsonism. Reetz K, et al. Neurobiol Dis, 2010 Sep. PMID 20483373.Lack of association between ATP13A2 Ala746Thr variant and Parkinson's disease in Han population of mainland China. Fei QZ, et al. Neurosci Lett, 2010 May 14. PMID 20227461.A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. Okada Y, et al. Hum Mol Genet, 2010 Jun 1. PMID 20189936.A new variant of the ATP13A2 gene in Chinese patients with early-onset parkinsonism. Wang L, et al. Chin Med J (Engl), 2009 Dec 20. PMID 20137506.
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