癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CLN3 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a full length recombinant CLN3.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q13286 |
| Other Accession | BC002394 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1G10 |
| Calculated MW | 47623 Da |
| Gene ID | 1201 |
|---|---|
| Other Names | Battenin, Batten disease protein, Protein CLN3, CLN3, BTS |
| Target/Specificity | CLN3 (AAH02394.1, 1 a.a. ~ 438 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CLN3 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene.
REFERENCES
Genotype does not predict severity of behavioural phenotype in juvenile neuronal ceroid lipofuscinosis (Batten disease). Adams HR, et al. Dev Med Child Neurol, 2010 Jul. PMID 20187884.Interaction between Sdo1p and Btn1p in the Saccharomyces cerevisiae model for Batten disease. Vitiello SP, et al. Hum Mol Genet, 2010 Mar 1. PMID 20015955.Common variants at five new loci associated with early-onset inflammatory bowel disease. Imielinski M, et al. Nat Genet, 2009 Dec. PMID 19915574.Protracted course of juvenile ceroid lipofuscinosis associated with a novel CLN3 mutation (p.Y199X). Sarpong A, et al. Clin Genet, 2009 Jul. PMID 19489875.S. pombe btn1, the orthologue of the Batten disease gene CLN3, is required for vacuole protein sorting of Cpy1p and Golgi exit of Vps10p. Codlin S, et al. J Cell Sci, 2009 Apr 15. PMID 19299465.
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