癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DVL3 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant DVL3.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q92997 |
| Other Accession | BC032459 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 4H2 |
| Calculated MW | 78055 Da |
| Gene ID | 1857 |
|---|---|
| Other Names | Segment polarity protein dishevelled homolog DVL-3, Dishevelled-3, DSH homolog 3, DVL3, KIAA0208 |
| Target/Specificity | DVL3 (AAH32459, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | DVL3 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.
REFERENCES
Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled. Gnad T, et al. Mol Cancer, 2010 Feb 5. PMID 20137080.Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein. Bouteille N, et al. Oncogene, 2009 Jul 16. PMID 19465938.Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma. Fukukawa C, et al. Oncogene, 2009 Feb 26. PMID 19137009.Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression. Wei Q, et al. Lung Cancer, 2008 Nov. PMID 18692936.Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. Lee YN, et al. Cell Signal, 2008 Feb. PMID 18093802.
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