癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
EPHX1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant EPHX1.
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | P07099 |
| Other Accession | BC008291 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2E8 |
| Calculated MW | 52949 Da |
| Gene ID | 2052 |
|---|---|
| Other Names | Epoxide hydrolase 1, Epoxide hydratase, Microsomal epoxide hydrolase, EPHX1, EPHX, EPOX |
| Target/Specificity | EPHX1 (AAH08291, 141 a.a. ~ 240 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | EPHX1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
REFERENCES
Association of Glutathione S-Transferase, EPHX, and p53 codon 72 Gene Polymorphisms with Adult Acute Myeloid Leukemia. Chauhan PS, et al. DNA Cell Biol, 2010 Aug 23. PMID 20731606.New genetic variant that might improve warfarin dose prediction in African Americans. Schelleman H, et al. Br J Clin Pharmacol, 2010 Sep. PMID 20716240.Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. Wang X, et al. PLoS One, 2010 Aug 3. PMID 20689807.Role of epoxide hydrolase 1 gene polymorphisms in esophageal cancer in a high-risk area in India. Ihsan R, et al. J Gastroenterol Hepatol, 2010 Aug. PMID 20659238.Influence of GSTs, CYP2E1 and mEH polymorphisms on 1, 3-butadiene-induced micronucleus frequency in Chinese workers. Tan H, et al. Toxicol Appl Pharmacol, 2010 Sep 15. PMID 20637790.
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