癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
EPOR Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant EPOR.
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, IP, E |
|---|---|
| Primary Accession | P19235 |
| Other Accession | NM_000121 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 3D10 |
| Calculated MW | 55065 Da |
| Gene ID | 2057 |
|---|---|
| Other Names | Erythropoietin receptor, EPO-R, EPOR |
| Target/Specificity | EPOR (NP_000112, 31 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IP~~N/A E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | EPOR Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
REFERENCES
A diversity of antibody epitopes can induce signaling through the erythropoietin receptor. Lim AC, et al. Biochemistry, 2010 May 11. PMID 20337434.STAT3 and hypoxia induced proteins--HIF-1alpha, EPO and EPOR in relation with Bax and Bcl-xL in nodal metastases of ductal breast cancers. Wincewicz A, et al. Folia Histochem Cytobiol, 2009 Jan. PMID 20164027.Absence of functional EpoR expression in human tumor cell lines. Swift S, et al. Blood, 2010 May 27. PMID 20124514.Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells. Sinclair AM, et al. Blood, 2010 May 27. PMID 20124513.Induction of nitric oxide by erythropoietin is mediated by the {beta} common receptor and requires interaction with VEGF receptor 2. Sautina L, et al. Blood, 2010 Jan 28. PMID 19965681.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
