癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
F2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant F2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IP, E |
|---|---|
| Primary Accession | P00734 |
| Other Accession | BC051332 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG |
| Clone Names | 1B7 |
| Calculated MW | 70037 Da |
| Gene ID | 2147 |
|---|---|
| Other Names | Prothrombin, Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain, F2 |
| Target/Specificity | F2 (AAH51332, 263 a.a. ~ 362 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IP~~N/A E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | F2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
REFERENCES
The association of protein S Tokushima-K196E with a risk of deep vein thrombosis. Ikejiri M, et al. Int J Hematol, 2010 Sep. PMID 20811787.Role of Genetic and Acquired Prothrombotic Risk Factors in Genesis of Sudden Sensorineural Hearing Loss. Fusconi M, et al. Audiol Neurootol, 2010 Aug 25. PMID 20798492.Risk of venous thrombosis in pregnancy among carriers of the factor V Leiden and the prothrombin gene G20210A polymorphisms. Jacobsen AF, et al. J Thromb Haemost, 2010 Aug 23. PMID 20735725.Prothrombotic state, cardiovascular and metabolic syndrome risk factors in prepubertal children born large-for-gestational age (LGA). Evagelidou EN, et al. Diabetes Care, 2010 Aug 19. PMID 20724652.Thrombophilic risk factors for placental stillbirth. Simchen MJ, et al. Eur J Obstet Gynecol Reprod Biol, 2010 Aug 11. PMID 20708329.
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