癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FRS2 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial length recombinant FRS2.
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8WU20 |
| Other Accession | BC021562 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1F7-1D6 |
| Calculated MW | 57029 Da |
| Gene ID | 10818 |
|---|---|
| Other Names | Fibroblast growth factor receptor substrate 2, FGFR substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1, SNT-1, FRS2 |
| Target/Specificity | FRS2 (AAH21562.1, 1 a.a. ~ 341 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FRS2 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway. Zhou W, et al. Cell Res, 2009 Oct. PMID 19652666.An in vitro analysis of mechanical wounding-induced ligand-independent KGFR activation. Li M, et al. J Dermatol Sci, 2009 Mar. PMID 19111446.Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform. Cha JY, et al. J Biol Chem, 2009 Mar 6. PMID 19103595.Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic. Turner ST, et al. Hypertension, 2008 Aug. PMID 18591461.Many sequence variants affecting diversity of adult human height. Gudbjartsson DF, et al. Nat Genet, 2008 May. PMID 18391951.
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