癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GPT Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a full length recombinant GPT.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P24298 |
| Other Accession | BC018207 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 4E3 |
| Calculated MW | 54637 Da |
| Gene ID | 2875 |
|---|---|
| Other Names | Alanine aminotransferase 1, ALT1, Glutamate pyruvate transaminase 1, GPT 1, Glutamic--alanine transaminase 1, Glutamic--pyruvic transaminase 1, GPT, AAT1, GPT1 |
| Target/Specificity | GPT (AAH18207.1, 1 a.a. ~ 496 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | GPT Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.
REFERENCES
Higher levels of alanine aminotransferase within the reference range predict unhealthy metabolic phenotypes of obesity in normoglycemic first-degree relatives of patients with type 2 diabetes mellitus. Mojiminiyi OA, et al. J Clin Hypertens (Greenwich), 2010 Apr. PMID 20433554.[Relations between ALT level and count of HBV special CTL and non-specific CTL in patients with chronic hepatitis B] Gu XB, et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi, 2009 Oct. PMID 20387481.Relation of coffee consumption and serum liver enzymes in Japanese men and women with reference to effect modification of alcohol use and body mass index. Ikeda M, et al. Scand J Clin Lab Invest, 2010 Apr 19. PMID 20205615.Relationship between serum HBV DNA level and liver histology in HBV carriers with normal ALT in Guilan province, Iran. Mansour-Ghanaei F, et al. Med Sci Monit, 2010 Feb 26. PMID 20190678.Usefulness of GPT for diagnosis of metabolic syndrome in obese Japanese children. Abe Y, et al. J Atheroscler Thromb, 2009. PMID 20032584.
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