癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GPT Antibody (N-term R133) 精选
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P24298 |
| Other Accession | A4IFH5 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54637 Da |
| Antigen Region | 118-144 aa |
| Gene ID | 2875 |
|---|---|
| Other Names | Alanine aminotransferase 1, ALT1, Glutamate pyruvate transaminase 1, GPT 1, Glutamic--alanine transaminase 1, Glutamic--pyruvic transaminase 1, GPT, AAT1, GPT1 |
| Target/Specificity | This GPT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-144 amino acids from the N-terminal region of human GPT. |
| Dilution | WB~~1:1000 IHC-P~~1:100 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPT Antibody (N-term R133) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GPT {ECO:0000303|PubMed:9119391, ECO:0000312|HGNC:HGNC:4552} |
|---|---|
| Function | Pyridoxal enzyme tha catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate (PubMed:11863375). By mediating the conversion of these four major intermediate metabolites, plays an important role in gluconeogenesis and amino acid metabolism (PubMed:11863375). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GPT(Glutamate-pyruvate transaminase), also known as alanine aminotransferase, catalyzes the reversible conversion of L-alanine and alpha-ketoglutarate to L-glutamate and pyruvate. This protein has 2 distinct molecular and genetic forms: one cytoplasmic (soluble) (GPT1) and one mitochondrial (GPT2). See ALTQTL1 and ALTQTL2 for information on quantitative trait loci influencing the plasma level of alanine aminotransferase.
REFERENCES
Yang R.-Z., Blaileanu G.Genomics 79:445-450(2002)
Ishiguro M., Takio K.Biochemistry 30:10451-10457(1991)
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