癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ISL1 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant ISL1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF |
|---|---|
| Primary Accession | P61371 |
| Other Accession | NM_002202 |
| Reactivity | Human, Rat |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2E8 |
| Calculated MW | 39036 Da |
| Gene ID | 3670 |
|---|---|
| Other Names | Insulin gene enhancer protein ISL-1, Islet-1, ISL1 |
| Target/Specificity | ISL1 (NP_002193, 63 a.a. ~ 159 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ISL1 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
REFERENCES
1.ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complex.Zhang Q, Yang Z, Jia Z, Liu C, Guo C, Lu H, Chen P, Ma K, Wang W, Zhou CMol Cancer. 2014 Jul 29;13(1):181. doi: 10.1186/1476-4598-13-181.2.A positive feedback regulation of ISL-1 in DLBCL but not in pancreatic β-cells.Zhang Q, Yang Z, Wang W, Guo T, Jia Z, Ma K, Zhou CBiochem Biophys Res Commun. 2014 Jul 4;449(3):295-300. doi: 10.1016/j.bbrc.2014.05.021. Epub 2014 May 15.3.Interaction of Wnt/?]-catenin and Notch signaling in the early stage of cardiac differentiation of P19CL6 cells.Li B, Jia Z, Wang T, Wang W, Zhang C, Chen P, Ma K, Zhou C.J Cell Biochem. 2011 Sep 28. doi: 10.1002/jcb.23390.4.ISL1 Promotes Pancreatic Islet Cell Proliferation.Guo T, Wang W, Zhang H, Liu Y, Chen P, Ma K, Zhou C.PLoS One. 2011;6(8):e22387. Epub 2011 Aug 4.
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