癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KYNU Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant KYNU.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q16719 |
| Other Accession | NM_003937 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Lambda |
| Clone Names | 1G2 |
| Calculated MW | 52352 Da |
| Gene ID | 8942 |
|---|---|
| Other Names | Kynureninase {ECO:0000255|HAMAP-Rule:MF_03017}, 3713 {ECO:0000255|HAMAP-Rule:MF_03017}, L-kynurenine hydrolase {ECO:0000255|HAMAP-Rule:MF_03017}, KYNU {ECO:0000255|HAMAP-Rule:MF_03017} |
| Target/Specificity | KYNU (NP_003928, 2 a.a. ~ 108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | KYNU Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Two transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Xanthurenic aciduria due to a mutation in KYNU encoding kynureninase. Christensen M, et al. J Inherit Metab Dis, 2007 Apr. PMID 17334708.[A polymorphism of kynureninase gene in a hypertensive candidate chromosomal region is associated with essential hypertension] Zhang Y, et al. Zhonghua Xin Xue Guan Bing Za Zhi, 2005 Jul. PMID 16080802.Enzymology of NAD+ homeostasis in man. Magni G, et al. Cell Mol Life Sci, 2004 Jan. PMID 14704851.Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
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