癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LASS6 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant LASS6.
- 产品详情
- 实验流程
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q6ZMG9 |
| Other Accession | NM_203463 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 5H7 |
| Calculated MW | 44890 Da |
| Gene ID | 253782 |
|---|---|
| Other Names | Ceramide synthase 6, CerS6, LAG1 longevity assurance homolog 6, CERS6, LASS6 |
| Target/Specificity | LASS6 (NP_982288, 62 a.a. ~ 131 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | LASS6 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1.Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.Jensen SA, Calvert AE, Volpert G, Kouri FM, Hurley LA, Luciano JP, Wu Y, Chalastanis A, Futerman AH, Stegh AHProc Natl Acad Sci U S A. 2014 Apr 15;111(15):5682-7. doi: 10.1073/pnas.1316700111. Epub 2014 Mar 31.2.Modulation of ceramide synthase activity via dimerization.Laviad EL, Kelly S, Merrill AH Jr, Futerman AH.J Biol Chem. 2012 Apr 26.3.D,l-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (DL-PDMP) increases endoplasmic reticulum stress, autophagy and apoptosis accompanying ceramide accumulation via ceramide synthase 5 protein expression in A549 cells.Yamane M, Miyazawa K, Moriya S, Abe A, Yamane S.Biochimie. 2011 May 7. [Epub ahead of print]4.Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R.Cell Signal. 2010 Apr 18. [Epub ahead of print]5.Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer.Ruckhaberle E, Holtrich U, Engels K, Hanker L, Gatje R, Metzler D, Karn T, Kaufmann M, Rody A.Climacteric. 2009 Jul 31:1-12. [Epub ahead of print]
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