癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LCN1 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant LCN1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P31025 |
| Other Accession | NM_002297 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1B11 |
| Calculated MW | 19250 Da |
| Gene ID | 3933 |
|---|---|
| Other Names | Lipocalin-1, Tear lipocalin, Tlc, Tear prealbumin, TP, Von Ebner gland protein, VEG protein, LCN1, VEGP |
| Target/Specificity | LCN1 (NP_002288, 24 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | LCN1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene belongs to the lipocalin family. Lipocalins are a group of extracellular proteins that are able to bind lipophiles by enclosure within their structures to minimize solvent contact. This protein may bind hydrophobic ligands and inhibit cysteine proteinases. It may also play a role in taste reception.
REFERENCES
A new crystal form of human tear lipocalin reveals high flexibility in the loop region and induced fit in the ligand cavity. Breustedt DA, et al. Acta Crystallogr D Biol Crystallogr, 2009 Oct. PMID 19770509.Intracavitary ligand distribution in tear lipocalin by site-directed tryptophan fluorescence. Gasymov OK, et al. Biochemistry, 2009 Aug 4. PMID 19586017.Tear lipocalin is the major endonuclease in tears. Yusifov TN, et al. Mol Vis, 2008 Jan 29. PMID 18334931.Evidence for internal and external binding sites on human tear lipocalin. Gasymov OK, et al. Arch Biochem Biophys, 2007 Dec 1. PMID 17945179.Oligomeric state of lipocalin-1 (LCN1) by multiangle laser light scattering and fluorescence anisotropy decay. Gasymov OK, et al. Biochim Biophys Acta, 2007 Oct. PMID 17869594.
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