癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MAPRE2 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant MAPRE2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, IF |
|---|---|
| Primary Accession | Q15555 |
| Other Accession | NM_014268 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 4D7 |
| Calculated MW | 37031 Da |
| Gene ID | 10982 |
|---|---|
| Other Names | Microtubule-associated protein RP/EB family member 2, APC-binding protein EB2, End-binding protein 2, EB2, MAPRE2, RP1 |
| Target/Specificity | MAPRE2 (NP_055083, 1 a.a. ~ 62 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MAPRE2 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR. Alternative splicing results in multiple transcript variants.
REFERENCES
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Molecular insights into mammalian end-binding protein heterodimerization. De Groot CO, et al. J Biol Chem, 2010 Feb 19. PMID 20008324.The microtubule-associated protein MAPRE2 is involved in perineural invasion of pancreatic cancer cells. Abiatari I, et al. Int J Oncol, 2009 Nov. PMID 19787265.Interactions between EB1 and microtubules: dramatic effect of affinity tags and evidence for cooperative behavior. Zhu ZC, et al. J Biol Chem, 2009 Nov 20. PMID 19778897.Suppression of microtubule dynamic instability by the +TIP protein EB1 and its modulation by the CAP-Gly domain of p150glued. Manna T, et al. Biochemistry, 2008 Jan 15. PMID 18081319.
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