癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MSI1 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a full length recombinant MSI1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | O43347 |
| Other Accession | NM_002442 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 1B11 |
| Calculated MW | 39125 Da |
| Gene ID | 4440 |
|---|---|
| Other Names | RNA-binding protein Musashi homolog 1, Musashi-1, MSI1 |
| Target/Specificity | MSI1 (NP_002433, 1 a.a. ~ 87 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MSI1 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13.
REFERENCES
Expression of putative stem cell genes Musashi-1 and beta1-integrin in human colorectal adenomas and adenocarcinomas. Fan LF, et al. Int J Colorectal Dis, 2010 Jan. PMID 19714342.Genomic analyses of musashi1 downstream targets show a strong association with cancer-related processes. de Sousa Abreu R, et al. J Biol Chem, 2009 May 1. PMID 19258308.Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells. Murayama M, et al. J Gastroenterol, 2009. PMID 19214660.Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy. Sanchez-Diaz PC, et al. BMC Cancer, 2008 Sep 30. PMID 18826648.Increased expression of the adult stem cell marker Musashi-1 in endometriosis and endometrial carcinoma. G?tte M, et al. J Pathol, 2008 Jul. PMID 18473332.
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