癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NUMA1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant NUMA1.
- 产品详情
- 实验流程
Application 
| WB, IP, E |
|---|---|
| Primary Accession | Q14980 |
| Other Accession | NM_006185 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1C5 |
| Calculated MW | 238260 Da |
| Gene ID | 4926 |
|---|---|
| Other Names | Nuclear mitotic apparatus protein 1 {ECO:0000312|HGNC:HGNC:8059}, NuMA protein, Nuclear matrix protein-22, NMP-22, SP-H antigen, NUMA1 (HGNC:8059) |
| Target/Specificity | NUMA1 (NP_006176, 200 a.a. ~ 306 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IP~~N/A E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | NUMA1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Centrosome-related genes, genetic variation, and risk of breast cancer. Olson JE, et al. Breast Cancer Res Treat, 2010 May 28. PMID 20508983.Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle. Woodard GE, et al. Mol Cell Biol, 2010 Jul. PMID 20479129.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly. Chang P, et al. Mol Biol Cell, 2009 Nov. PMID 19759176.Inhibiting Crm1 causes the formation of excess acentriolar spindle poles containing NuMA and B23, but does not affect centrosome numbers. Rousselet A. Biol Cell, 2009 Sep 14. PMID 19522705.
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