癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
OTX1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant OTX1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P32242 |
| Other Accession | NM_014562 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1F2 |
| Calculated MW | 37327 Da |
| Gene ID | 5013 |
|---|---|
| Other Names | Homeobox protein OTX1, Orthodenticle homolog 1, OTX1 |
| Target/Specificity | OTX1 (NP_055377, 10 a.a. ~ 116 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | OTX1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy.
REFERENCES
Expression of the homeobox genes OTX2 and OTX1 in the early developing human brain. Larsen KB, et al. J Histochem Cytochem, 2010 Jul. PMID 20354145.Expression of the brain transcription factor OTX1 occurs in a subset of normal germinal-center B cells and in aggressive Non-Hodgkin Lymphoma. Omodei D, et al. Am J Pathol, 2009 Dec. PMID 19893048.Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Eeles RA, et al. Nat Genet, 2009 Oct. PMID 19767753.Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967.Expression of the homeobox genes PAX6, OTX2, and OTX1 in the early human fetal retina. Larsen KB, et al. Int J Dev Neurosci, 2009 Aug. PMID 19414065.
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