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>   首页   >   产品   >   一抗   >   代谢   >   PARK2 Antibody (monoclonal) (M01)   

PARK2 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant PARK2.

     
  • 1 - PARK2 Antibody (monoclonal) (M01) AT3182a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • 1 - PARK2 Antibody (monoclonal) (M01) AT3182a
    PARK2 monoclonal antibody (M01), clone 1H4 Western Blot analysis of PARK2 expression in Jurkat ( (Cat # AT3182a )
  • 3 - PARK2 Antibody (monoclonal) (M01) AT3182a
    Immunofluorescence of monoclonal antibody to PARK2 on HeLa cell. [antibody concentration 10 ug/ml]
  • 10 - PARK2 Antibody (monoclonal) (M01) AT3182a
    Detection limit for recombinant GST tagged PARK2 is 0.1 ng/ml as a capture antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, E
Primary Accession O60260
Other Accession BC022014
Reactivity Human
Host mouse
Clonality monoclonal
Isotype IgG3 Kappa
Clone Names 1H4
Calculated MW 51641 Da
Additional Information
Gene ID 5071
Other Names E3 ubiquitin-protein ligase parkin, 632-, Parkinson juvenile disease protein 2, Parkinson disease protein 2, PARK2, PRKN
Target/Specificity PARK2 (AAH22014, 288 a.a. ~ 387 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
IF~~1:50~200
E~~N/A
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsPARK2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

REFERENCES

1.Regional and cellular localisation of Parkin Co-Regulated Gene in developing and adult mouse brain.Brody KM, Taylor JM, Wilson GR, Delatycki MB, Lockhart PJ.Brain Res. 2008 Mar 27;1201:177-86. Epub 2008 Jan 30.

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