癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PPA1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant PPA1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q15181 |
| Other Accession | NM_021129 |
| Reactivity | Human, Rat |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 3B2 |
| Calculated MW | 32660 Da |
| Gene ID | 5464 |
|---|---|
| Other Names | Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase, PPA1, IOPPP, PP |
| Target/Specificity | PPA1 (NP_066952, 10 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PPA1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme.
REFERENCES
Localization of the structural genes for hexokinase-1 and inorganic pyrophosphatase on region (pter-->q24) of human chromosome 10. Chern CJ. Cytogenet Cell Genet, 1976. PMID 17494625.[Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system] Maksimov VV, et al. Genetika, 2006 Feb. PMID 16583711.Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. Guo D, et al. Biochem Biophys Res Commun, 2005 Dec 2. PMID 16236267.A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Bruneel A, et al. Proteomics, 2005 Oct. PMID 16130169.
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