癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PTGES2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant PTGES2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H7Z7 |
| Other Accession | NM_025072 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 5B7 |
| Calculated MW | 41943 Da |
| Gene ID | 80142 |
|---|---|
| Other Names | Prostaglandin E synthase 2, Membrane-associated prostaglandin E synthase-2, mPGE synthase-2, Microsomal prostaglandin E synthase 2, mPGES-2, Prostaglandin-H(2) E-isomerase, Prostaglandin E synthase 2 truncated form, PTGES2, C9orf15, PGES2 |
| Target/Specificity | PTGES2 (NP_079348, 270 a.a. ~ 377 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PTGES2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene.
REFERENCES
Microsomal prostaglandin E synthase-2: cellular distribution and expression in Alzheimer's disease. Chaudhry U, et al. Exp Neurol, 2010 Jun. PMID 19664621.Microsomal prostaglandin E synthase protein levels correlate with prognosis in colorectal cancer patients. Seo T, et al. Virchows Arch, 2009 Jun. PMID 19412621.Association analysis between the prostaglandin E synthase 2 R298H polymorphism and body mass index in 8079 participants of the KORA study cohort. Fischer A, et al. Genet Test Mol Biomarkers, 2009 Apr. PMID 19371221.The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas. Mattila S, et al. Neuropathology, 2009 Apr. PMID 19347995.Determination of genetic predisposition to patent ductus arteriosus in preterm infants. Dagle JM, et al. Pediatrics, 2009 Apr. PMID 19336370.
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