癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RAB21 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant RAB21.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | Q9UL25 |
| Other Accession | NM_014999 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1F6 |
| Calculated MW | 24348 Da |
| Gene ID | 23011 |
|---|---|
| Other Names | Ras-related protein Rab-21, RAB21, KIAA0118 |
| Target/Specificity | RAB21 (NP_055814, 116 a.a. ~ 225 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | RAB21 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
RAB21 belongs to the RAB family of small GTP-binding proteins that regulate intracellular vesicle targeting (Opdam et al., 2000 [PubMed 10887961]).
REFERENCES
Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth. Burgo A, et al. EMBO Rep, 2009 Oct. PMID 19745841.Integrin trafficking regulated by Rab21 is necessary for cytokinesis. Pellinen T, et al. Dev Cell, 2008 Sep. PMID 18804435.Structural basis for Rab GTPase activation by VPS9 domain exchange factors. Delprato A, et al. Nat Struct Mol Biol, 2007 May. PMID 17450153.Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. Pellinen T, et al. J Cell Biol, 2006 Jun 5. PMID 16754960.The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901.
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