癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SETX Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant SETX.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q7Z333 |
| Other Accession | NM_015046 |
| Reactivity | Human, Mouse, Rat |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2A9 |
| Calculated MW | 302880 Da |
| Gene ID | 23064 |
|---|---|
| Other Names | Probable helicase senataxin, 364-, Amyotrophic lateral sclerosis 4 protein, SEN1 homolog, SETX, ALS4, KIAA0625, SCAR1 |
| Target/Specificity | SETX (NP_055861.2, 2579 a.a. ~ 2676 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SETX Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4).
REFERENCES
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Exon deletions and intragenic insertions are not rare in ataxia with oculomotor apraxia 2. Bernard V, et al. BMC Med Genet, 2009 Sep 11. PMID 19744353.Characterization of two novel SETX mutations in AOA2 patients reveals aspects of the pathophysiological role of senataxin. Airoldi G, et al. Neurogenetics, 2010 Feb. PMID 19593598.Ataxia with oculomotor apraxia type 2: novel mutations in six patients with juvenile age of onset and elevated serum alpha-fetoprotein. Bernard V, et al. Neuropediatrics, 2008 Dec. PMID 19569000.Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation. Suraweera A, et al. Hum Mol Genet, 2009 Sep 15. PMID 19515850.
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