癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC26A5 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant SLC26A5.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P58743 |
| Other Accession | NM_198999 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1F4 |
| Calculated MW | 81264 Da |
| Gene ID | 375611 |
|---|---|
| Other Names | Prestin, Solute carrier family 26 member 5, SLC26A5, PRES |
| Target/Specificity | SLC26A5 (NP_945350, 645 a.a. ~ 742 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SLC26A5 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Genotyping with a 198 mutation arrayed primer extension array for hereditary hearing loss: assessment of its diagnostic value for medical practice. Rodriguez-Paris J, et al. PLoS One, 2010 Jul 26. PMID 20668687.Structure of the cytosolic portion of the motor protein prestin and functional role of the STAS domain in SLC26/SulP anion transporters. Pasqualetto E, et al. J Mol Biol, 2010 Jul 16. PMID 20471983.Cysteine mutagenesis reveals transmembrane residues associated with charge translocation in prestin. McGuire RM, et al. J Biol Chem, 2010 Jan 29. PMID 19926791.Mutation-induced reinforcement of prestin-expressing cells. Kumano S, et al. Biochem Biophys Res Commun, 2009 Nov 27. PMID 19737539.Structural rearrangements of the motor protein prestin revealed by fluorescence resonance energy transfer. Gleitsman KR, et al. Am J Physiol Cell Physiol, 2009 Aug. PMID 19515900.
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