癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC33A1 Antibody (monoclonal) (M07)
Mouse monoclonal antibody raised against a partial recombinant SLC33A1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O00400 |
| Other Accession | NM_004733 |
| Reactivity | Human, Rat |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3A4 |
| Calculated MW | 60909 Da |
| Gene ID | 9197 |
|---|---|
| Other Names | Acetyl-coenzyme A transporter 1, AT-1, Acetyl-CoA transporter 1, Solute carrier family 33 member 1, SLC33A1, ACATN, AT1 |
| Target/Specificity | SLC33A1 (NP_004724, 1 a.a. ~ 69 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SLC33A1 Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family, but not in similar patients of European descent. Two transcript variants encoding the same protein have been found for this gene.
REFERENCES
1.SLC33A1/AT-1 regulates the induction of autophagy down-stream of IRE1/XBP1.Pehar M, Jonas MC, Hare TM, Puglielli L.J Biol Chem. 2012 Jul 11.2.AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability.Jonas MC, Pehar M, Puglielli L.J Cell Sci. 2010 Oct 1;123(Pt 19):3378-88. Epub 2010 Sep 7.
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