癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SP1 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant SP1.
- 产品详情
- 实验流程
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | P08047 |
| Other Accession | NM_138473 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 |
| Clone Names | 4C8 |
| Calculated MW | 80693 Da |
| Gene ID | 6667 |
|---|---|
| Other Names | Transcription factor Sp1, SP1, TSFP1 |
| Target/Specificity | SP1 (NP_612482, 89 a.a. ~ 198 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SP1 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. Jutooru I, et al. J Biol Chem, 2010 Aug 13. PMID 20538607.Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73gamma in lung cancer. Logotheti S, et al. FEBS J, 2010 Jul. PMID 20528922.Regulation of plasma-membrane-associated sialidase NEU3 gene by Sp1/Sp3 transcription factors. Yamaguchi K, et al. Biochem J, 2010 Aug 15. PMID 20518744.Transcription factor Sp1 regulates expression of cancer-associated molecule CD147 in human lung cancer. Kong LM, et al. Cancer Sci, 2010 Jun. PMID 20384626.HDAC4 inhibits the transcriptional activation of mda-7/IL-24 induced by Sp1. Pan L, et al. Cell Mol Immunol, 2010 May. PMID 20383178.
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