癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
YAP1 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant YAP1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | P46937 |
| Other Accession | NM_006106 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2H1 |
| Calculated MW | 54462 Da |
| Gene ID | 10413 |
|---|---|
| Other Names | Transcriptional coactivator YAP1, Yes-associated protein 1, Protein yorkie homolog, Yes-associated protein YAP65 homolog, YAP1, YAP65 |
| Target/Specificity | YAP1 (NP_006097, 53 a.a. ~ 161 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | YAP1 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.
REFERENCES
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties. Liu AM, et al. Biochem Biophys Res Commun, 2010 Apr 9. PMID 20226166.Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer. Wang Y, et al. Cancer Sci, 2010 May. PMID 20219076.Yap is a novel regulator of C2C12 myogenesis. Watt KI, et al. Biochem Biophys Res Commun, 2010 Mar 19. PMID 20153295.A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Zhao B, et al. Genes Dev, 2010 Jan 1. PMID 20048001.
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