PPARA Antibody
Purified Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB, IHC-P, IF, FC |
---|---|
Primary Accession | Q07869 |
Reactivity | Human, Mouse |
Host | Mouse |
Clonality | Monoclonal |
Calculated MW | 52225 Da |
Isotype | IgG1,κ |
Antigen Source | HUMAN |
Gene ID | 5465 |
---|---|
Other Names | Peroxisome proliferator-activated receptor alpha, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1, PPARA, NR1C1, PPAR |
Dilution | WB~~1:500 IHC-P~~1:100~500 IF~~1:25 FC~~1:25 |
Target/Specificity | This PPARA antibody is generated from a mouse immunized with a recombination protein from the human region of human PPARA. |
Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PPARA Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PPARA |
---|---|
Synonyms | NR1C1, PPAR |
Function | Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. |
Cellular Location | Nucleus. |
Tissue Location | Skeletal muscle, liver, heart and kidney. Expressed in monocytes (PubMed:28167758). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.
REFERENCES
Sher T.,et al.Biochemistry 32:5598-5604(1993).
Mukherjee R.,et al.J. Steroid Biochem. Mol. Biol. 51:157-166(1994).
Tugwood J.D.,et al.Ann. N. Y. Acad. Sci. 804:252-265(1996).
Kobayashi T.,et al.FEBS Lett. 582:2737-2744(2008).
Cho M.-C.,et al.Immunopharmacol. Immunotoxicol. 31:459-467(2009).

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