癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
(Mouse) Msi1 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB |
|---|---|
| Primary Accession | Q61474 |
| Other Accession | Q8K3P4, O43347 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 39119 Da |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 17690 |
|---|---|
| Antigen Region | 81-113 aa |
| Other Names | RNA-binding protein Musashi homolog 1, Musashi-1, Msi1, Msi1h |
| Dilution | WB~~1:1000 |
| Target/Specificity | This mouse Msi1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 81-113 amino acids from the Central region of mouse Msi1. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | (Mouse) Msi1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Msi1 |
|---|---|
| Synonyms | Msi1h |
| Function | RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU- 3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system. |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Expressed in neural stem and progenitor cells (at protein level) (PubMed:16554442). Detected in olfactory bulb, brain stem, small intestine, and at low levels in brain cortex, hippocampus and ovary (PubMed:8660864). Detected in neural progenitor cells, including neural stem cells (PubMed:8660864) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'- GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'- [GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.
REFERENCES
Sakakibara S.,et al.Dev. Biol. 176:230-242(1996).
Carninci P.,et al.Science 309:1559-1563(2005).
Imai T.,et al.Mol. Cell. Biol. 21:3888-3900(2001).
Sakakibara S.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:15194-15199(2002).
Nagata T.,et al.J. Mol. Biol. 287:315-330(1999).
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