CCL23

Product Information
Primary Accession	P55773
Species	Human
Sequence	RFHATSADCC ISYTPRSIPC SLLESYFETN SECSKPGVIF LTKKGRRFCA NPSDKQVQVC VRMLKLDTRI KTRKN
Purity	> 95% as analyzed by SDS-PAGE.
Endotoxin Level	< 0.2 EU/ µg, determined by LAL method.
Formulation	Lyophilized after extensive dialysis against PBS.
Reconstitution	Reconstituted in ddH₂O or PBS at 100 µg/ml.

Additional Information
Other Names	C-C motif chemokine 23, CK-beta-8, CKB-8, Macrophage inflammatory protein 3, MIP-3, Myeloid progenitor inhibitory factor 1, MPIF-1, Small-inducible cytokine A23, CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99), CCL23, MIP3, MPIF1, SCYA23
Target Background	Myeloid progenitor inhibitory factor 1 (MPIF-1), also known as Chemokine (C-C motif) ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family. MPIF-1 is predominantly expressed in lung and liver tissue, but is also found in bone marrow and placenta. It is also expressed in some cell lines of myeloid origin. It is highly chemotactic for resting T cells and monocytes and slightly chemotactic for neutrophils. MPIF-1 has been shown to inhibit colony formation of bone marrow myeloid immature progenitors. It has also been attributed to an inhibitory activity on hematopoietic progenitor cells. MPIF-1 is a ligand for the chemokine receptor CCR1. Recombinant human MPIF-1/CCL23 (aa46-120) produced in CHO cells is a single polypeptide chain containing 75 amino acids. A fully biologically active molecule, rhMPIF-1/CCL23 (aa46-120) has a molecular mass of 11.3 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at .