癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CNTF
- 产品详情
- 实验流程
| Primary Accession | P51642 |
|---|---|
| Species | Mouse |
| Sequence | Ala2-Met198 |
| Purity | > 95% as analyzed by SDS-PAGE |
| Endotoxin Level | < 0.2 EU/ µg of protein by gel clotting method |
| Biological Activity | ED50 < 30.0 ng/ml, measured by its ability to induce alkaline phosphatase production by TF-1 Cells. |
| Expression System | E. coli |
| Formulation | Lyophilized after extensive dialysis against PBS |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 µg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
| Gene ID | 12803 |
|---|---|
| Other Names | Ciliary neurotrophic factor, CNTF, Cntf |
| Target Background | Ciliary Neurotrophic Factor (CNTF) is a polypeptide hormone which acts within the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. CNTF is a potent survival factor for neurons and oligodendrocytes and may play a role in reducing tissue damage during increased inflammation. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, however this phenotype is not causally related to neurologic disease. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Cntf {ECO:0000312|MGI:MGI:88439} |
|---|---|
| Function | Functions as a cytokine through the ciliary neurotrophic factor receptor (CNTFR) complex. The CNTFR complex indeed consists of the membrane-anchored non-signaling receptor CNTFR and the two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell. Functionally, promotes neuronal survival, supports differentiation of various neuronal and non-neuronal cells, and importantly regulates oligodendrocyte progenitor proliferation. Mechanistically, ligand binding to the CNTFR induces dimerization of the IL6ST/gp130 and LIFR, which activates JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STAT3 and to lesser extent STAT1). Can also signal via trans-signaling using soluble forms of CNTFR (By similarity). Seems to prevent the degeneration of motor axons after axotomy (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P26441}. Secreted {ECO:0000250|UniProtKB:Q02011}. Note=The precursor semms to be cytoplasmic (By similarity). The lack of a specific hydrophobic segment in the precursor sequence suggests that CNTF is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins (By similarity). {ECO:0000250|UniProtKB:P20294, ECO:0000250|UniProtKB:P26441} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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