癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Gli3 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P10071 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB6105 |
| Calculated MW | 169863 Da |
| Gene Name | GLI3 |
| Aliases | GLI Family Zinc Finger 3; PAP-A; PAPA1; PPDIV; PAPA; PAPB; ACLS; Glioma-Associated Oncogene Family Zinc Finger 3; GLI-Kruppel Family Member GLI3;Transcriptional Activator GLI3; Zinc Finger Protein GLI3; Oncogene GLI3; GLI3-190; GLI3FL; GCPS; PHS; Greig Cephalopolysyndactyly Syndrome; GLI3 Full-Length Protein; GLI3 Form Of 190 KDa; DNA-Binding Protein |
| Immunogen | A synthesized peptide derived from human Gli3 |
| Gene ID | 2737 |
|---|---|
| Other Names | Transcriptional activator GLI3, GLI3 form of 190 kDa, GLI3-190, GLI3 full-length protein, GLI3FL, Transcriptional repressor GLI3R, GLI3 C-terminally truncated form, GLI3 form of 83 kDa, GLI3-83, GLI3 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GLI3 {ECO:0000303|PubMed:2118997, ECO:0000312|HGNC:HGNC:4319} |
|---|---|
| Function | Transcription factor that acts as a key effector of the smoothened signaling pathway, and which plays a role in the development and patterning of various body structures, including the brain and limbs (PubMed:10075717, PubMed:10375510, PubMed:10693759, PubMed:11238441, PubMed:17764085, PubMed:20154143, PubMed:27146893). Specifically binds to the minimal GLI-consensus sequence 5'-GACCACCCA- 3' to activate or repress the expression of target genes (PubMed:10075717). Functions both as a transcriptional activator and repressor: the full-length GLI3 form (Transcription activator GLI3) acts as a transcription activator following smoothened activation, while the Transcription repressor GLI3R, which is generated in absence of smoothened, acts as a transcription repressor (PubMed:10375510). The repressor form (GLI3R) constitutes the major form of GLI3 (PubMed:10375510). |
| Cellular Location | Nucleus. Cytoplasm. Cell projection, cilium. Note=Full-length GLI3 is sequestered in the cytoplasm by SUFU in absence of smoothened signaling [Transcription activator GLI3]: Nucleus. Cytoplasm Cell projection, cilium Note=Sequestered in the cytoplasm by SUFU in absence of smoothened signaling (PubMed:38968120). Accumulates in primary cilia following smoothened activation: cilium localization requires the presence of KIF7 (PubMed:19592253, PubMed:20154143). It then translocates to the nucleus, where is activates transcription of target genes (PubMed:38968120). Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441). TMEM216 reduces its nuclear localization (By similarity). {ECO:0000250|UniProtKB:Q61602, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19592253, ECO:0000269|PubMed:20154143, ECO:0000269|PubMed:38968120} |
| Tissue Location | Is expressed in a wide variety of normal adult tissues, including lung, colon, spleen, placenta, testis, and myometrium. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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