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MLLT4 antibody - N-terminal region
Rabbit Polyclonal Antibody
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- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P55196 |
| Other Accession | P55196, EAW47480, NM_001040000 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine, Yeast |
| Predicted | Human, Mouse, Rat, Zebrafish, Chicken, Dog, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 206804 Da |
| Gene ID | 4301 |
|---|---|
| Alias Symbol | RP3-470B24.4, AF-6, AF6, AFADIN, FLJ34371, RP3-431P23.3 |
| Other Names | Afadin, ALL1-fused gene from chromosome 6 protein, Protein AF-6, MLLT4, AF6 |
| Target/Specificity | AF6 is a Ras target that regulates cell-cell adhesions downstream of Ras activation. It is fused with MLL in leukemias caused by t(6, 11) translocations. |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-MLLT4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | MLLT4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AFDN (HGNC:7137) |
|---|---|
| Synonyms | AF6, MLLT4 |
| Function | Belongs to an adhesion system, probably together with the E- cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). |
| Cellular Location | Cell junction, adherens junction. Note=Not found at cell-matrix AJs {ECO:0000250|UniProtKB:O35889} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This is a rabbit polyclonal antibody against MLLT4. It was validated on Western Blot using a cell lysate as a positive control. Abgent strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (sales@abgent.com).
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