癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SUFU antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q9UMX1 |
| Other Accession | NM_016169, NP_057253 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Horse |
| Predicted | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Chicken, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 53947 Da |
| Gene ID | 51684 |
|---|---|
| Alias Symbol | PRO1280, SUFUH, SUFUXL |
| Other Names | Suppressor of fused homolog, SUFUH, SUFU |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SUFU antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | SUFU antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SUFU {ECO:0000303|PubMed:12068298, ECO:0000312|HGNC:HGNC:16466} |
|---|---|
| Function | Negative regulator in the hedgehog/smoothened signaling pathway that acts by sequestering the GLI (GI1, GLI2 and GLI3) transcription factors in the cytoplasm (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:12068298, PubMed:12975309, PubMed:15367681, PubMed:22365972, PubMed:24217340, PubMed:24311597, PubMed:27234298, PubMed:28965847, PubMed:35831023). When smoothened signaling is initiated, GLI transcription factors dissociate from SUFU, translocate to the nucleus and activate expression of target genes (PubMed:24311597, PubMed:28965847, PubMed:35831023). In absence of smoothened signaling, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of full-length GLI3 into transcription repressor GLI3R: SUFU participates to GLI3 processing by promoting recruitment of GSK3B to GLI3 (PubMed:24311597, PubMed:28965847). May also act as a negative regulator of beta-catenin signaling (By similarity). Required for normal embryonic development (By similarity). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity). |
| Cellular Location | Cytoplasm. Nucleus. Cell projection, cilium {ECO:0000250|UniProtKB:Q9Z0P7}. Note=Recruited to cilia in response to smoothened signaling, leading to dissociation from GLI (GI1, GLI2 and GLI3) transcription factors. {ECO:0000250|UniProtKB:Q9Z0P7} |
| Tissue Location | Ubiquitous in adult tissues. Detected in osteoblasts of the perichondrium in the developing limb of 12-week old embryos. Isoform 1 is detected in fetal brain, lung, kidney and testis Isoform 2 is detected in fetal testis, and at much lower levels in fetal brain, lung and kidney. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Lee,D.Y., (2007) Proc. Natl. Acad. Sci. U.S.A. 104 (51), 20350-20355 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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