癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
C15orf48 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9C002 |
| Other Accession | NM_032413, NP_115789 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Dog, Guinea Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 9617 Da |
| Gene ID | 84419 |
|---|---|
| Alias Symbol | FLJ22645, FOAP-11, MGC32925, NMES1 |
| Other Names | Normal mucosa of esophagus-specific gene 1 protein, Protein FOAP-11, NMES1, C15orf48 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-C15orf48 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | C15orf48 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | COXFA4L3 (HGNC:29898) |
|---|---|
| Function | Mitochondrial small peptide that orchestrates a two-pronged immunoregulatory mechanism in response to inflammatory stimuli. Replaces the canonical cytochrome c oxidase subunit COXFA4 in mitochondrial complex IV and targets it to degradation, attenuating mitochondrial respiration, reducing membrane potential as well as ROS generation and modulates innate immune signaling (PubMed:33837217, PubMed:34878835). Additionally, initiates stress-independent autophagy by lowering ATP levels, activating AMPK-ULK1 signaling, boosting glutathione production, and thereby mitigating oxidative stress and supporting immune tolerance (PubMed:38296961). |
| Cellular Location | Mitochondrion inner membrane; Single-pass membrane protein |
| Tissue Location | Expressed mainly in stomach, placenta, small intestine and colon, as well as in normal mucosa of esophagus. Down- regulated in esophageal squamous cell carcinoma (PubMed:12209954) Expressed in macrophages (PubMed:34878835) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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