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MTNR1A antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P48039 |
| Other Accession | NM_005958, NP_005949 |
| Reactivity | Human, Rabbit, Goat, Dog, Guinea Pig, Horse, Bovine, Sheep |
| Predicted | Human, Bovine, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 39375 Da |
| Gene ID | 4543 |
|---|---|
| Alias Symbol | MEL-1A-R, MT1 |
| Other Names | Melatonin receptor type 1A, Mel-1A-R, Mel1a receptor, MTNR1A |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-MTNR1A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | MTNR1A antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MTNR1A |
|---|---|
| Function | High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Possibly involved in sleep induction, by melatonin activation of the potassium channel KCNMA1/BK and the dissociation of G-beta and G-gamma subunits, thereby decreasing synaptic transmission (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Reppert S.M.,et al.Neuron 13:1177-1185(1994).
Ebisawa T.,et al.Biochem. Biophys. Res. Commun. 262:832-837(1999).
Huang Y.-H.,et al.Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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