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Anti-Melatonin Receptor 1a Antibody

Rabbit polyclonal antibody to Melatonin Receptor 1a

     
  • 1 - Anti-Melatonin Receptor 1a Antibody AP60190
    Western blot analysis of Melatonin Receptor 1a expression in mouse brain (A), rat kidney (B), HEK293T (C), HCT116 (D) whole cell lysates.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P48039
Other Accession Q61184
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 39375 Da
Additional Information
Gene ID 4543
Other Names Melatonin receptor type 1A; Mel-1A-R; Mel1a receptor
Target/Specificity Recognizes endogenous levels of Melatonin Receptor 1a protein.
Dilution WB~~WB (1/500 - 1/1000)
Format Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide.
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name MTNR1A
Function High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Possibly involved in sleep induction, by melatonin activation of the potassium channel KCNMA1/BK and the dissociation of G-beta and G-gamma subunits, thereby decreasing synaptic transmission (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Melatonin Receptor 1a. The exact sequence is proprietary.

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