CYK18 Antibody (C-term)
Mouse Monoclonal Antibody (Mab)
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Application ![]()
| WB, E |
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Primary Accession | P05783 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG3 |
Clone Names | 695CT17.2.6 |
Calculated MW | 48058 Da |
Gene ID | 3875 |
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Other Names | Keratin, type I cytoskeletal 18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, CK-18, Keratin-18, K18, KRT18, CYK18 |
Target/Specificity | This CYK18 Monoclonal antibody is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the 400-430 region of human CYK18. |
Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CYK18 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KRT18 |
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Synonyms | CYK18 |
Function | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. |
Cellular Location | Nucleus matrix {ECO:0000250|UniProtKB:Q5BJY9}. Cytoplasm, perinuclear region. Nucleus, nucleolus. Cytoplasm {ECO:0000250|UniProtKB:Q5BJY9} |
Tissue Location | Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
REFERENCES
Oshima R.G., et al. Differentiation 33:61-68(1986).
Kim J.W., et al. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N., et al. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Suzuki Y., et al. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Kulesh D.A., et al. Mol. Cell. Biol. 8:1540-1550(1988).

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