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Anti-Trop-2/TACSTD2 (Extracellular region) Antibody

     
  • 2 - Anti-Trop-2/TACSTD2 (Extracellular region) Antibody AN1988
    Immunocytochemical labeling of Trop-2 in paraformaldehyde fixed human A431 cells. The cells were labeled with mouse monoclonal anti-Trop-2 (clone M005). The antibody was detected using goat anti-mouse DyLight® 594.
  • 10 - Anti-Trop-2/TACSTD2 (Extracellular region) Antibody AN1988
    Representative Standard Curve using mouse monoclonal anti-Trop-2 (AN1988) for ELISA capture of human recombinant Trop-2 extracellular region with His-tag. Capture was detected by using an anti-His-tag antibody followed by appropriate secondary antibody conjugated to HRP.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, ICC, IP
Primary Accession P09758
Host Mouse
Clonality Mouse Monoclonal
Isotype IgG1
Clone Names M005
Calculated MW 35709 Da
Additional Information
Gene ID 4070
Other Names Tumor-associated calcium signal transducer 2; Trop-2; Membrane component chromosome 1 surface marker 1; GA733-1; TACSTD2; M1S1; TROP2
Dilution WB~~1:1000
ICC~~N/A
IP~~N/A
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAnti-Trop-2/TACSTD2 (Extracellular region) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Trop-2 (TACSTD2) is a transmembrane glycoprotein found on invasive trophoblast cells and in several epithelial type cancer cells. Trop-2 has an extracellular domain with EGF thyroglobulin type-1 repeats, a transmembrane domain and a short cytoplasmic tail with a HIKE domain containing a PIP2 binding site. This glycoprotein functions in many signaling pathways including interaction of its extracellular domain with integrin β1 to regulate FAK signaling, interaction of its transmembrane domain with claudin 1 and claudin 7 during tight junction formation, and regulation of intracellular calcium release by its PIP2 binding and activation of the ERK/MAPK pathway. These Trop-2 functions may be important during tumor proliferation, metastasis and invasion.

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