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RALY Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - RALY Antibody (Center) AP16333c
    RALY Antibody (Center) (Cat. #AP16333c) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the RALY antibody detected the RALY protein (arrow).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9UKM9
Other Accession NP_057951.1, NP_031393.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 32463 Da
Antigen Region 75-103 aa
Additional Information
Gene ID 22913
Other Names RNA-binding protein Raly, Autoantigen p542, Heterogeneous nuclear ribonucleoprotein C-like 2, hnRNP core protein C-like 2, hnRNP associated with lethal yellow protein homolog, RALY, HNRPCL2, P542
Target/Specificity This RALY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-103 amino acids from the Central region of human RALY.
Dilution WB~~1:1000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRALY Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RALY
Synonyms HNRPCL2, P542
Function RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid- responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q64012}.
Tissue Location Expressed in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Weakly expressed in placenta
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

In infectious mononucleosis, anti-EBNA-1 antibodies are produced which cross-react with multiple normal human proteins. The cross-reactivity is due to anti-gly/ala antibodies that cross-react with host proteins containing configurations like those in the EBNA-1 repeat. One such antigen is RALY which is a member of the heterogeneous nuclear ribonucleoprotein gene family. [provided by RefSeq].

REFERENCES

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)

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