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>   首页   >   产品   >   一抗   >   信号转导   >   RAB27B Antibody (C-term)   

RAB27B Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - RAB27B  Antibody (C-term) AP4986b
    Western blot analysis of RAB27B Antibody (C-term) (Cat. #AP4986b) in NCI-H460 cell line lysates (35ug/lane). RAB27B (arrow) was detected using the purified Pab.
  • 4 - RAB27B  Antibody (C-term) AP4986b
    RAB27B Antibody (C-term) (Cat. #AP4986b) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, FC, E
Primary Accession O00194
Other Accession NP_004154
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 24608 Da
Antigen Region 186-215 aa
Additional Information
Gene ID 5874
Other Names Ras-related protein Rab-27B, C25KG, RAB27B
Target/Specificity This RAB27B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-215 amino acids from the C-terminal region of human RAB27B.
Dilution WB~~1:1000
FC~~1:10~50
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRAB27B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAB27B
Function Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity).
Cellular Location Membrane; Lipid-anchor. Late endosome
Tissue Location Expressed primarily in testis.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

RAB27B may be involved in targeting uroplakins to urothelial apical membranes.

REFERENCES

Hayasaka, S., et al. Asian J. Androl. 10(4):561-568(2008)
Shirakawa, R., et al. J. Biol. Chem. 279(11):10730-10737(2004)
Tiwari, S., et al. Blood 102(12):3970-3979(2003)

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