癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RAB30 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | Q15771 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 23058 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human RAB30 |
| Epitope Specificity | 131-203/203 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell membrane. |
| SIMILARITY | Belongs to the small GTPase superfamily. Rab family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Gene ID | 27314 |
|---|---|
| Other Names | Ras-related protein Rab-30, RAB30 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | RAB30 (HGNC:9770) |
|---|---|
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:22188167). RAB30 is required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins (PubMed:22188167). Facilitates lipid homeostasis during fasting by regulating hepatic protein and lipid trafficking in a PPAR-alpha-dependent manner (By similarity). Promotes autophagosome biogenesis during bacterial infection such as group A Streptococcus infection (PubMed:26771875). |
| Cellular Location | Membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans- Golgi network membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus membrane. Cytoplasm. Cytoplasmic vesicle, autophagosome membrane. Autolysosome membrane. Note=Localized to dynamic membranes fusing to and exiting from the Golgi apparatus (By similarity) Localized to group A Streptococcus (GAS)-containing autophagosome to autolysosome in GAS-infected epithelial cells (PubMed:26771875). Also colocalized with a starvation-induced autophagosome although not required for autophagosome formation during starvation (PubMed:26771875). {ECO:0000250|UniProtKB:Q923S9, ECO:0000269|PubMed:26771875} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,500.00
Cat# AP57633
