癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
UEVLD Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q8IX04 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52264 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human UEVLD |
| Epitope Specificity | 85-180/471 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | In the N-terminal section; belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.In the C-terminal section; belongs to the LDH/MDH superfamily.Contains 1 UEV (ubiquitin E2 variant) domain. |
| SUBUNIT | Homodimer. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | UEV3, also known as EV and lactate/malate dehydrogenase domain-containing protein, is a 471 amino acid protein that contains one UEV (ubiquitin E2 variant) domain, which typically interacts with ubiquitin. UEV3 is thought to be a paralogue of tsg 101, a protein that exerts regulatory effects on E2 activity in cellular ubiquitination processes. With amino-terminal homology to the catalytic domain of ubiquitin-conjugating enzymes, it is thought that UEV3 may function as a negative regulator of polyubiquitination. UEV3 is expressed in various colon carcinoma cell lines, carcinomas of the uterine cervix and peripheral blood leukocytes as well as normal colon and cervical epithelium. |
| Gene ID | 55293 |
|---|---|
| Other Names | Ubiquitin-conjugating enzyme E2 variant 3, UEV-3, EV and lactate/malate dehydrogenase domain-containing protein, UEVLD {ECO:0000312|EMBL:AAH64566.1} |
| Target/Specificity | Colon, colon carcinoma cell lines, normal cervical epithelium, carcinomas of the uterine cervix and peripheral blood leukocytes. |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4) with 1% BSA, 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | UEVLD {ECO:0000312|EMBL:AAH64566.1} |
|---|---|
| Function | Possible negative regulator of polyubiquitination. |
| Tissue Location | Colon, colon carcinoma cell lines, normal cervical epithelium, carcinomas of the uterine cervix and peripheral blood leukocytes. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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