BMP-3A Polyclonal Antibody

Western Blot analysis of Jurkat cells using BMP-3A Polyclonal Antibody. Antibody was diluted at 1:500. Secondary antibody was diluted at 1:20000
Immunohistochemical analysis of paraffin-embedded human-liver-cancer, antibody was diluted at 1:100
Immunohistochemical analysis of paraffin-embedded human-liver-cancer, antibody was diluted at 1:100
Immunohistochemical analysis of paraffin-embedded mouse-muscle, antibody was diluted at 1:100

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P
Primary Accession	P12645
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Calculated MW	53372 Da

Additional Information
Gene ID	651
Other Names	BMP3; BMP3A; Bone morphogenetic protein 3; BMP-3; Bone morphogenetic protein 3A; BMP-3A; Osteogenin
Dilution	WB~~Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications. IHC-P~~N/A
Format	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide.
Storage Conditions	-20℃

Protein Information
Name	BMP3
Synonyms	BMP3A
Function	Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification (PubMed:11138004, PubMed:15269709). Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways (PubMed:31665064).
Cellular Location	Secreted.
Tissue Location	Expressed in adult and fetal cartilage.