ERAP1 Rabbit mAb
- 产品详情
- 实验流程
Application ![]()
| WB, IHC-P |
---|---|
Primary Accession | Q9NZ08 |
Reactivity | Human, Rat |
Host | Rabbit |
Clonality | Monoclonal Antibody |
Calculated MW | 107235 Da |
Gene ID | 51752 |
---|---|
Other Names | ERAP1 |
Dilution | WB~~1/500-1/1000 IHC-P~~N/A |
Format | Liquid |
Name | ERAP1 |
---|---|
Synonyms | APPILS, ARTS1, KIAA0525 |
Function | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein |
Tissue Location | Ubiquitous. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.

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Cat# AP75107