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>   首页   >   产品   >   一抗   >   其他   >   Transcriptional Enhancer Factor TEF Rabbit mAb   

Transcriptional Enhancer Factor TEF Rabbit mAb

     
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q15561
Reactivity Human
Host Rabbit
Clonality Monoclonal Antibody
Calculated MW 48329 Da
Additional Information
Gene ID 7004
Other Names TEAD4
Dilution WB~~1/500-1/1000
Format Liquid
Protein Information
Name TEAD4
Synonyms RTEF1, TCF13L1, TEF3
Function Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
Cellular Location Nucleus.
Tissue Location Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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