癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MLK2 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 2
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q02779 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 103694 Da |
| Antigen Region | 628-659 aa |
| Gene ID | 4294 |
|---|---|
| Other Names | Mitogen-activated protein kinase kinase kinase 10, Mixed lineage kinase 2, Protein kinase MST, MAP3K10, MLK2, MST |
| Target/Specificity | This MLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 628-659 amino acids from the C-terminal region of human MLK2. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MLK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAP3K10 |
|---|---|
| Synonyms | MLK2, MST |
| Function | Activates the JUN N-terminal pathway. |
| Tissue Location | Expressed in brain and skeletal muscle. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
MLK2 is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
REFERENCES
Dorow, D.S., et al., Eur. J. Biochem. 234(2):492-500 (1995).
Katoh, M., et al., Oncogene 10(7):1447-1451 (1995).
Dorow, D.S., et al., Eur. J. Biochem. 213(2):701-710 (1993).
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