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>   首页   >   产品   >   重组兔单克隆抗体   >   重组兔单克隆抗体   >   Sprouty 4 Antibody   

Sprouty 4 Antibody

Rabbit mAb

     
  • 1 - Sprouty 4 Antibody AP91718
    Western blot analysis of Sprouty 4 expression in MCF7 cell lysate.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, FC, ICC, IP
Primary Accession Q9C004
Reactivity Rat, Human, Mouse
Clonality Monoclonal
Other Names Sprouty homolog 4; SPRY 4;
Isotype Rabbit IgG
Host Rabbit
Calculated MW 32541 Da
Additional Information
Dilution WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:50 FC 1:50
Purification Affinity-chromatography
Immunogen A synthesized peptide derived from human Sprouty 4
Description Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras.
Storage Condition and Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Protein Information
Name SPRY4
Function Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893). Probably impairs the formation of GTP-Ras (PubMed:12027893). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898).
Cellular Location Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor) (By similarity). Colocalizes with TESK1 in vesicular spots in the cytoplasm (PubMed:15584898) {ECO:0000250|UniProtKB:Q9WTP2, ECO:0000269|PubMed:15584898}
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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